“With immense gratitude for his example as a true disciple of the Lord Jesus, we commend the soul of Pope Francis to the infinite merciful love of the One and Triune God.”

The process for choosing a new pope – conclave – generally takes place between 15 and 20 days after the death of a pontiff.

In recent years, his papacy had been marked by several hospital visits and concerns about his health. On 14 February, the Pope was admitted to hospital for bronchitis treatment.

In the days that followed, the Vatican said he had been diagnosed with bilateral pneumonia and that he had blood transfusions after tests revealed he had low levels of platelets in his blood, which is associated with anaemia.

On 22 February, it said the Pope was in a critical condition after a “prolonged respiratory crisis” that required a high flow of oxygen, and the next day the Vatican said Francis was showing an “initial, mild” kidney failure.

In the following days, thousands of faithful gathered in St Peter’s Square to pray for his recovery, as others went to the Rome hospital where he was staying to leave flowers and cards.

He remained in hospital for the rest of the month, with doctors saying that his condition remained “complex”.

On 6 March, his voice was heard for the first time since being admitted to hospital in an audio message, in which he thanked well-wishers, before adding: “I am with you from here.”

On Sunday, he greeted crowds at the Easter Sunday Service, a day after meeting US Vice president JD Vance.

His 38-day hospital stay ended on 23 March when he made his first public appearance in five weeks on a balcony at Gemelli where he smiled and gave a thumbs up to the crowds gathered outside.

He returned to the Vatican, making a surprise stop at his favourite basilica on the way home, before beginning two months of prescribed rest and recovery.

Doctors said Francis would have access to supplemental oxygen and 24-hour medical care as needed – adding that while the pneumonia infection had been successfully treated, the pontiff would continue to take oral medication for quite some time to treat the fungal infection in his lungs and continue his respiratory and physical physiotherapy.

Born in 1936, Francis was the first Pope from South America. His papacy was marked by his championing of those escaping war and hunger, as well as those in poverty, earning him the moniker the “People’s Pope”.

In 2016, he washed the feet of refugees from different religions at an asylum centre outside Rome in a “gesture of humility and service”.

He also made his views known on a wide range of issues, from climate change to wealth inequality and the role of women in the Catholic Church.

His acceptance of the LGBTQ community was unprecedented – beginning with an unexpected remark to reporters on a flight back from Brazil about gay clergy.

He said: “If a person is gay and seeks God and has good will, who am I to judge them?”

However, in April 2024 he appeared to reiterate the Vatican’s staunch opposition to gender reassignment, surrogacy, abortion and euthanasia, by signing the text “Dignitas Infinita” (Infinite Dignity).

In the same year, his own liberal credentials were questioned after reports he used a homophobic slur behind closed doors.

As a young man in his native Argentina, Francis had part of one lung removed.

In the last few years of his life, Francis needed a wheelchair or a cane to get around and limited his public speaking while struggling with bronchitis and flu.

Francis first spent time in hospital as Pope in 2021 for an operation to remove part of his colon.

In June 2023 he was admitted to hospital for an operation on his intestine. At the time, the Vatican said he had been suffering “recurrent, painful and worsening” symptoms caused by an abdominal hernia.

His recent health issues meant he was forced to miss significant events in the Roman Catholic calendar, including the traditional Good Friday procession at Rome’s Colosseum last year.

In 2022, he hinted he might step down if his health deteriorated after he was pictured using a wheelchair due to mobility issues caused by a flare-up of sciatica – a nerve condition that causes leg pain.

His predecessor, the late Benedict XVI, became the first pope to resign in more than 600 years in 2013 instead of serving for life, and died in 2022.

The Pope’s original name was Jorge Mario Bergoglio and he previously served as a bishop in Buenos Aires.

An estimated 1.4 billion Catholics across the world will mourn Francis’ passing.